ABSTRACT
Open field activity was studied in Wistar rats. Animals with low scores of ambulatory and rearing behaviours were grouped as hypoactive and those with high scores as hyperactive. Acquisition of active avoidance learning in a shuttle box was studied in the two groups. Hyperactive rats in contrast to hypoactive rats showed a better acquisition of avoidance learning. Learning was suppressed in both groups by domperidone, but was facilitated by immobilisation stress in the hypoactive group only. The two groups did not differ in the basal and stress evoked heart rates. These observations suggest that immobilisation stress favours enhancement of the dopaminergic related behaviour like avoidance learning in hypoactive rats.
Subject(s)
Animals , Avoidance Learning/physiology , Behavior, Animal/physiology , Dopamine/physiology , Exploratory Behavior/physiology , Heart Rate/physiology , Hyperkinesis/physiopathology , Male , Motor Activity/physiology , Rats , Rats, Wistar , Restraint, Physical , Stress, Physiological/physiopathologyABSTRACT
A rapid dot enzyme immuno assay (Dot ELISA) for rabies antibody estimation has been standardized in which nitrocellulose sheet has been used as a solid support absorbing a commercial tissue culture rabies vaccine as antigen. The test was compared with a standard plate ELISA test. The results were comparable and the student "t' test for proportion revealed that plate ELISA test is significantly better (P 0.05) when compared to Dot ELISA for the number of sera with titre < 0.5 Iu/ml and in the case of > 0.5 IU/ml Dot ELISA is found to be better over plate ELISA test at the same significance level.